Advocates’ guide to doxycycline to prevent bacterial STIs (DoxyPEP)

Doxycycline, an oral antibiotic commonly referred to as DoxyPEP, is a post-exposure prophylaxis used to prevent the acquisition of some bacterial STIs after sex. Doxycycline is inexpensive, easily tolerated, and widely available. However, questions remain regarding who will benefit most from DoxyPEP and how to implement this strategy broadly to ensure equitable access. This guide seeks to explore and address these critical questions.